First observation of Hb Tunis [beta124(H2)Pro>Ser] in Turkey.

نویسندگان

  • Aylin Köseler
  • Hasan Koyuncu
  • Onur Öztürk
  • Anzel Bahadır
  • Sanem Demirtepe
  • Ayfer Atalay
  • Erol Ömer Atalay
چکیده

Hb Tunis [beta124(H2)Pro>Ser] was reported from Tunisia in 1988. This hemoglobin variant was detected by isoelectric focusing moving just ahead of Hb A. It cannot be identified by standard hemoglobin electrophoresis due to its similar mobility to Hb A. It has normal stability and oxygen affinity and does not produce any clinical symptoms. Here, we report a heterozygous Hb Tunis [beta124(H2)Pro>Ser] case discovered for the first time in Turkey in a premarital screening program. This hemoglobin variant can be identified with high performance liquid chromatography analysis confirmed with DNA sequencing. We emphasize in our study the importance of an interdisciplinary collaborative study at the provincial basis for the success of the hemoglobinopathy control program.

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عنوان ژورنال:
  • Turkish journal of haematology : official journal of Turkish Society of Haematology

دوره 27 2  شماره 

صفحات  -

تاریخ انتشار 2010